Academic Publications

Published Researches

Dr Aydin's research focuses on QEEG-guided neuromodulation and its applications in autism spectrum disorder, contributing to the growing evidence base for personalised brain stimulation therapies. All publications are peer-reviewed and available on ResearchGate.

Research Focus

Dr Aydin's research programme investigates the neurophysiological mechanisms underlying autism spectrum disorder and the efficacy of non-invasive neuromodulation interventions. Using quantitative EEG (QEEG) as both a diagnostic and monitoring tool, this work aims to develop more personalised and effective treatment approaches.

Key research areas include QEEG-guided repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and the development of home-based neuromodulation protocols. The research particularly focuses on social communication outcomes and behavioral improvements in children and adolescents with ASD.

This translational research bridges clinical practice and academic investigation, with findings directly informing treatment protocols at Cosmos Healthcare while contributing to the broader scientific understanding of neuromodulation in neurodevelopmental conditions.

Methodology & Approach

All research follows rigorous scientific methodology, combining quantitative neurophysiological measures with validated clinical outcome assessments. Studies utilise pre- and post-intervention QEEG analysis to objectively measure changes in brain function, alongside standardised behavioural and developmental assessments to evaluate real-world improvements in patients' daily functioning.

Dr Aydin's research is published in peer-reviewed journals and presented at international conferences, contributing to the growing evidence base for precision neuromodulation in autism spectrum disorder. This commitment to research ensures that treatment approaches remain at the forefront of clinical neuroscience, offering patients access to the most advanced, evidence-based interventions available.

Research Areas

  • QEEG Brain Mapping
  • rTMS for ASD
  • tDCS Protocols
  • Excitation-Inhibition Balance
  • Social Communication
  • Home-Based Neuromodulation

Research Collaboration

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2025 Publications

November 2025 Article · Full-text available

Mixed-Frequency rTMS Rapidly Modulates Multiscale EEG Biomarkers of Excitation–Inhibition Balance in Autism Spectrum Disorder: A Single-Case Report

Alptekin Aydin

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established neuromodulatory method, yet its multiscale neurophysiological effects in autism spectrum disorder (ASD) remain insufficiently characterized. Recent EEG analytic advances—such as spectral parameterization, long-range temporal correlation (LRTC) assessment, and connectivity analysis—offer new insights into excitation-inhibition balance and neural dynamics that may clarify how rTMS exerts its effects.

Methods: We present a single-case study of a young adult male with ASD who underwent a mixed-frequency rTMS protocol targeting the dorsolateral prefrontal cortex (DLPFC). QEEG assessments were conducted pre- and post-intervention using a 19-channel montage. We analyzed spectral power, aperiodic (1/f) slope, theta/beta ratio (TBR), detrended fluctuation analysis (DFA) exponents, and coherence/phase-lag index (PLI) metrics.

October 2025 Article · Full-text available

QEEG-Guided rTMS in Pediatric ASD with Contextual Evidence on Home-Based tDCS: Within-Cohort Reanalysis and Narrative Contextualization

Alptekin Aydin

Background: Autism Spectrum Disorder (ASD) affects approximately 1 in 36 children and is increasingly studied as a candidate for non-invasive neuromodulation. Two of the most widely applied modalities are quantitative EEG (QEEG)-guided repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), both targeting the dorsolateral prefrontal cortex (DLPFC).

This study presents a within-cohort reanalysis of QEEG-guided rTMS outcomes in pediatric ASD, contextualized alongside emerging evidence for home-based tDCS interventions. The research examines treatment response patterns, optimal dosing parameters, and the role of baseline QEEG characteristics in predicting outcomes.

March 2025 Article · Full-text available

Assessing the Impact of Transcranial Direct Current Stimulation (tDCS) Over the Dorsolateral Prefrontal Cortex on Social Communication in Children and Adolescents with Autism Spectrum Disorder (ASD)

Alptekin Aydin

Introduction: Autism Spectrum Disorder (ASD) is characterized by persistent difficulties in social communication and behavior regulation. Although behavioral and pharmacological interventions exist, many yield limited improvements in these core areas. Transcranial Direct Current Stimulation (tDCS), a non-invasive neuromodulation technique, offers a promising adjunctive approach by modulating cortical excitability in regions associated with social cognition and executive function.

This study evaluated the effects of anodal tDCS applied over the left DLPFC on social communication outcomes in a cohort of children and adolescents with ASD, using standardized assessment measures and caregiver-reported outcomes.

January 2025 Article · Full-text available

Comparative Efficacy of QEEG-Guided rTMS and Home-Based tDCS for Social Communication and Behavioral Outcomes in Autism Spectrum Disorder: A Parallel Cohort Analysis

Alptekin Aydin

This study examines deficits manifesting as social emotional reciprocity: diminished sharing of affect, failure of back-and-forth conversation, or reduced interest in peers. It investigates nonverbal communicative behaviours including atypical eye gaze, facial expressions, prosody, or gesture integration, as well as difficulties in developing, maintaining and understanding relationships.

Using parallel cohort methodology, this research directly compares outcomes between clinic-based QEEG-guided rTMS and supervised home-based tDCS protocols, providing valuable insights into the relative efficacy and practical considerations of each approach for families and clinicians.

Access All Publications

All research papers are available in full-text on ResearchGate. For research collaboration enquiries, clinical consultations, or media requests, please get in touch.

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